Introduction
Vitamin
D is an essential factor, not only for homeostasis of calcium and phosphorus
but also for cell proliferation, differentiation and apoptosis, immune and
hormonal regulation as well as other body processes.
Vitamin
D also known as the sunshine vitamin as it is
produced by the body in response to sunlight. It occurs naturally in a few
foods including some fish, fish liver oils, and egg yolks and in fortified
dairy and grain products.
Where to get vitamin D
The
principal source of vitamin D is forming our own
skin. A chemical compound called 7-dehydrocholesterol, naturally present
in the superficial layers of the skin, is converted, on exposure to ultra
violet B (UV-B) radiation, to a compound called pre vitamin D, which
spontaneously changes in to cholecalciferol (vitamin D3). Small quantity of vitamin Dis also available
in food, but unlike the other vitamins most foods do not contain appreciable
amount of this micronutrient.
There
are two forms of vitamin D, known as D2 and D3
Vitamin
D2, also known as ergocalciferol, comes from fortified foods, plant food, and supplements.
Vitamin
D3 also known as cholecalciferol comes from fortified foods, animal foods (fish
eggs and liver) and can be made internally when skin is exposed to ultraviolet
radiation from the sun.
Vitamin
D deficiency is common in India more than 90%of apparently healthy Indians have
sub-normal vitamin D levels. The prevalence of vitamin D deficiency or insufficiency
is very high in iron deficient women. this means that it is stored in our fat
cells and is constantly being used for calcium metabolism and bone remodelling
.if your exposure to sun is less suffer from milk allergies or adhere to a
strict vegetarian diet you may be at risk for vitamin D deficiency .
Vitamin
D deficiency & its prevention from tracking to treatment, prevention and
relief.
What is active vitamin D?
The
body converts vitamin D, whether taken orally or synthesized in the skin, to a
compound called 25-hydroxyvitamin-D (0H)D The body converts up to 100mg of
25(OH)D each day in to a further compound called calcitriol, which is the
active form of vitamin D that help the body to signal the decoding of dna
blueprints for over 200 human genes.
Health maintenance and vitamin D
Vitamin
D promotes calcium absorption in the gut and
maintains adequate serum calcium and phosphate concentration to enable normal
mineralization of bone and to prevent hypocacemic tetany. It is needed for bone
growth and bone remodeling by osteoblast and osteoclast.
Vitamin
D sufficiency prevents rickets in children and osteomalasia in adult. Together
with calcium, vitamin D also helps to protect older adults from osteoporosis.
Causes –
ร Latitude,
culture dress habits, season, sun avoidance, and sunscreen protection all limit
vitamin D production
ร Gastrointestinal
hepatic and renal disease may be related to low vitamin D levels
ร Hypo
vitaminosis D results from lack of UVB exposure.
ร Dark
skin as the pigment melanin reduces the skin ability to make vitamin D in
response to sunlight exposure.
ร Certain
medical problems including crohn s disease, cystic fibrosis, and celiac disease,
can affect intestines ability to absorb vitamin D form the food.
ร obesity
Recovery time
Recovery
from this deficiency may take about few months it mainly depends on the type of
the treatment and lifestyle of the individual
Diagnosis
Diagnosis
is done mainly by 25-hydroxy vitamin D blood test
Medicines
are available in the form of oral tablets, injections and sachets.
Symptoms
There
is no clear pattern of symptoms. Many people have no symptoms despite low
levels .the common symptoms including
1.
Fatigue
2.
Chronic pain
3.
Weight gain
4.
General muscle pain,
weakness and cramps
5.
Joint pain
6.
Sleep disturbances
7.
Poor
concentration
8.
Headache
9.
Bladder problems
Diarrhoea or constipation
High blood pressure
Severe
vitamin D insufficiency may cause rickets in children and osteomalascia and
osteoporosis in adult.
To do
To
increase vitamin D level in the body stay around 15-30 minutes a day in the
summer sun without sunscreen.
Take
a vitamin D3 supplement if you are in a low sunlight region
Women
over 40 if deficient in vitamin D are at increased risk of osteoporosis, and
should take vitamin D supplement if found deficient
Vitamin D and
general health
Beside
treating and preventing A range of disease, vitamin D has been applied in
managing minor abnormalities so as to improve quality of life .
Cancer – garland et al.
were the first to propose that vitamin D deficiency may contribute to a higher
risk of colon cancer mortality since vitamin D is formed in the skin through
solar UV-B radiation. The protective relationship between sufficient vitamin D
status and lower risk of cancer has been found in many studies.
It
has been reported that breast and colorectal cancer can be reduced by50/ with
the concentration of 25ohd
Tuberculosis-
recently it was found that low vitamin D status resulting from a vegetarian
diet is an independent risk factor for active TB.
One
study measuring 192 healthy adult who came in contact with TB, showed that a
single oral dose of 2.5mg vitamin D significantly enhanced participant whole
blood ability to restrict functional whole blood
Vitamin
D has also been found to play an important role in brain development and
function
Periodontal
disease is a common chronic inflammatory disease characterized by loss of
periodontal attachment. A 3 year study showed that supplementation with vitamin
D (700IU/d) plus calcium (500mg/d) significantly
reduced tooth loss in older people.
Prevention
ร Allow yourself limited, unprotected sun exposure
ร Eat a diet rich in whole foods
ร Take a top quality multivitamin every day
ร Take a vitamin D supplement
Discuss
adding a vitamin D supplement to your diet with your doctor/healthcare provider
Key massages
·
Vitamin D is a vital link
for human body to be healthy. Vitamin D is mainly available as D2 and D3
·
Vitamin D3 has higher
potency and longer duration of action compared with vitamin D2
·
Adequate intake of vitamin
D is directly linked to
·
Improvement in BMD and is
important in preventing osteoporosis and osteopenia
·
Reduction in incidence of
type 2 diabetes mellitus
·
Reduction I cancer incidence,
cell differentiation, apoptosis and metastasis. Increased vitamin D and calcium
intake decreases the risk of developing colon cancer
·
Vitamin D intake and
exposure to UV_B radiation result in a substantial improvement in BMD and is
important in prevention osteoporosis and increase in 25(OH)d concentration and
has a positive effect in the management of hypertension in adults
·
Vitamin D is necessary to
maintain fertility and reproductive health in women
·
Vitamin D is necessary to
maintain fertility and reproductive health in women
·
Vitamin D has also been
found to play an important role in brain development and function along with
prevention of periodontal disease
·
A potential physiological
role for vitamin D in regulating normal innate and adaptive immunity has been
demonstrated in many studies which prevent RA and MS
·
Epidemiological and
clinical studies indicate innumerable benefits of vitamin D. supplementation
with vitamin D3 help in maintaining a healthy and disease free body.
Recommendation
·
Ideal sun exposure the
best time for vitamin D synthesis is between 11 to 2 pm and it should be to the
bare skin of as much body as possible e.g. face, neck hands forearms ect. The
required duration of time required to turn the skin pink or to have burning
sensation.
·
General shift workers
should use the lunch hour and Sundays while employees with rotating duties can
utilize evening & night shift days to get adequate sun exposure.
·
Milk intake through milk
is not a great source regular intake of at least 500ml milk /day is recommended
particularly for vegetarians
·
People with dark skin
elderly smokers having chronic illness like DM, epilepsy are more likely to
develop the deficiency .they should follow the recommendation s more mesticusly
or they should take supplements on periodic basis.
·
Extra care should be taken
for females in pregnancy & lactation phases, as there is high chance of
developing insufficiency and it may have lasting effects on bone strength of
the off springs.
·
Sunscreens shall be used
very judiciously
Conclusion
Vitamin
D deficiency and insufficiency Is very widely prevalent than once thought. It
is under diagnosed in most health set ups. The possible reasons of low vitamin
D levels are as follows
·
Reduced direct sun
exposure – largely due to lifestyle changes and preferences for comforts has
led to minimal time spent outdoors in the ideal times.
·
Job profile & demands
– more and more time being spent inside buildings by most shop floors control
room and office workers. The continuous monitoring required in control rooms
shop floors leave very less chance of sun exposure for workers.
·
Smoking – smoking &
use of sunscreens are known to increase the risk of vitamin D deficiency
·
Use of PPEs – as per
safety requirements all filed workers
have to were mandatory PPEs including full sleeves , gloves helmets goggles
leaving minimum skin exposed to direct sun light.